You will italicize the title of the video game, as it's the name of a standalone, self-contained work -- a work that is complete in and of itself, like a book or movie or painting. You also want to make sure you note the version of the game and which platform it was played on.
Narratively, this would look like:
The sequel The Last of Us Part II, released in 2020, revisits an older version of the character...
The sophistication of graphics processing has seen a leap from the simple geometry of Pong to the first 3D games like Sonic Adventure, and today games can choose anything from a practically photorealistic The Last of Us Part II to minimalist Minecraft.
Side note: Yes, you will read articles online in which game titles are not italicized. Those writers are following a different style guide! MLA wants italics. (As does
APA 7.)
In a Works Cited citation:
The Last of Us Part II. Developed by Naughty Dog, Playstation 4, Sony Interactive Entertainment, 2020.
